How membrane structures control T cell signaling
نویسندگان
چکیده
منابع مشابه
How membrane structures control T cell signaling.
Genetic and biochemical studies have identified a large number of molecules involved in T cell signaling. They have provided us with a comprehensive understanding of protein-protein interactions and protein modifications that take place upon antigen recognition. Diffraction limited fluorescence microscopy has been used to study the distribution of signaling molecules on a cellular level. Specif...
متن کاملRecent Advances in T Cell Signaling in Aging
The immune system of mammalian organisms undergoes alterations that may account for an increased susceptibility to certain infections, autoimmune diseases, or malignancies. Well characterized are age related defect in T cell functions and cell mediated immunity. Although it is well established that the functional properties of T cells decrease with age, its biochemical and molecular nature is...
متن کاملIntroducing Membrane Charge and Membrane Potential to T Cell Signaling
While membrane models now include the heterogeneous distribution of lipids, the impact of membrane charges on regulating the association of proteins with the plasma membrane is often overlooked. Charged lipids are asymmetrically distributed between the two leaflets of the plasma membrane, resulting in the inner leaflet being negatively charged and a surface potential that attracts and binds pos...
متن کاملThe roles of clustered membrane proteins in T-cell signaling
Humans, like most other jawed vertebrates, are equipped with an adaptive immune system that can respond to diverse pathogens. Mature T cells, one of the most important immune cells generated from the thymus through a rigorous selection processes, are key orchestrators of the immune responses. Although many of the key signaling molecules in T cells have been discovered, the underlying mechanisms...
متن کاملNew Insights into How Trafficking Regulates T Cell Receptor Signaling
There is emerging evidence that exocytosis plays an important role in regulating T cell receptor (TCR) signaling. The trafficking molecules involved in lytic granule (LG) secretion in cytotoxic T lymphocytes (CTL) have been well-studied due to the immune disorder known as familial hemophagocytic lymphohistiocytosis (FHLH). However, the knowledge of trafficking machineries regulating the exocyto...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Immunology
سال: 2012
ISSN: 1664-3224
DOI: 10.3389/fimmu.2012.00291